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Nathan Goodyear

Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian pros... - 0 views

  • GI is a measure of carbohydrate quality in relation to glucose availability and is independent of quantity, whereas GL is a measure of the total glycemic effect and hence is anindicator of the insulin demand of the diet. High-glycemic diets are in fact generally associated with greater insulin secretion
  • the consumption of large quantities of high-GI foods rather than the consumption of high quantities of carbohydrates is linked to the development of breast cancer.
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    High glycemic load and glycemic index associated with increased breast cancer risk in premenopausal women.
Nathan Goodyear

Dietary glycemic index, glycemic load, and cancer risk: results from the EPIC-Italy stu... - 0 views

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    High glycemic index diet was found to be associated with increased risk of colon and bladder cancer where as a high glycemic load was associated with increased risk of colon cancer and other diabetes-related cancers.
Nathan Goodyear

Influence of high-carbohydrate mixed meals with different glycemic indexes on substrate... - 0 views

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    low-glycemic index diet aids in mobilization of adipose tissue in exercise.  In this study, exercise after a low-glycemic meal resulted in a greater mobilization of adipose tissue for energy production than a high glycemic meal.  This will help  in weight loss
Nathan Goodyear

International Tables of Glycemic Index and Glycemic Load Values: 2008 - 1 views

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    Great article from 2008 that discusses glycemic index and glycemic load.  What is great about this article is the supplementary appendix listing the above for > 1000 items.
Nathan Goodyear

http://annonc.oxfordjournals.org/content/12/11/1533.full.pdf#page=1&view=FitH - 0 views

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    Study finds link between higher glycemic index and glycemic load with increased breast cancer risk.   The proposed mechanisms are: hyperinsulinemia and its affinity for IGF-1 receptor resulting in a + growth signal.  Increased IGF-1 via the same mechanism. Insulin and IGF-1 have negative regulation effects on SHBG. This all makes sense as insulin receptors are highly expressed on cancer cells.
Nathan Goodyear

The effect of a low-carbohydrate, ketogenic diet versus a low-glycemic index diet on gl... - 0 views

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    low carb ketogenic diet outperforms low glycemic index in diabetes.
Nathan Goodyear

Effect of a low glycemic index compared with a conventional healthy diet on polycystic ... - 0 views

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    low glycemic diet for ladies with polycystic ovaries
Nathan Goodyear

A low-glycemic index diet combined with exerc... [Am J Clin Nutr. 2010] - PubMed - NCBI - 0 views

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    low glycemic index diet improves insulin and glucose control in pre-diabetics
Nathan Goodyear

Effects of Weight Loss and Long-Term Weight Maintenance With Diets Varying in Protein a... - 0 views

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    High protein and high glycemic index intake are both associated with low grade inflammation.  An associated increase in cardiovascular risk was additionally found.
Nathan Goodyear

Dietary treatment of the metabolic syndrome--the o... [Br J Nutr. 2000] - PubMed - NCBI - 0 views

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    low glycemic index diet is treatment of choice for metabolic syndrome
Nathan Goodyear

Dietary glycemic index and glycemic load and breast cancer risk in the European Prospec... - 0 views

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    high carbohydrate intake associated with increased risk of ER/PR negative breast cancer in Postmenopausal women.
Nathan Goodyear

Metabolic effects of testosterone replacement therapy on hypogonadal men with type 2 di... - 0 views

  • up to 40% of men with T2DM have testosterone deficiency
  • Among diabetic patients, a reduction in sex hormone binding globulin levels induced by insulin resistance leads to a further decline of testosterone levels
  • low bioavailable testosterone concentration was related to decreased lean body mass and muscle strength
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  • Testosterone deficiency has a high prevalence in men with T2DM, and it is also associated with impaired insulin sensitivity, increased percentage body fat, central obesity, dyslipidemia, hypertension and cardiovascular diseases (CVD)
  • A meta-analysis of four randomized controlled trials (RCTs) showed that TRT seemed to improve glycemic control as well as fat mass in T2DM subjects with low testosterone levels and sexual dysfunction.
  • testosterone administration could increase muscle mass and strength
  • Insulin stimulates glucose uptake into muscle and adipose tissue via the Glut4 glucose transporter isoform. When insulin activates signaling via the insulin receptor, Glut4 interacts with insulin receptor substrate 1 to initialize intracellular signaling and facilitate glucose transportation into the cell
  • The benefits of TRT on glucose metabolism can mainly be explained by its influence on the insulin signaling pathway
  • Insulin resistance as assessed by, which is calculated from the equation (If*Gf/22.5, where If is fasting insulin and Gf is fasting glucose), was definitely improved by TRT after testosterone administration in three studies
  • Testosterone was observed to elevate the expression levels and stimulate translocation of Glut4 in cultured skeletal muscle cells and to upregulate Glut4 by activating insulin receptor signaling pathways in neonatal rats
  • These effects were inhibited by a dihydrotestosterone (DHT) blocker, indicating that glucose uptake may correlate with conversion of testosterone to DHT and activation of the androgen receptor.
  • TRT reduced triglyceride levels
  • TRT has been reported to have a positive effect in the decrease of total and LDL cholesterol levels and triglycerides in hypogonadal men
  • a recent meta-analysis showed that statins could significantly lower testosterone concentrations.
  • Epidemiological studies have found a negative relationship between testosterone levels and typical cardiovascular risk markers, such as body mass index, waist circumference, visceral adiposity and carotid intima-media thickness.
  • Testosterone treatment was shown to raise hemoglobin, hematocrit and thromboxane, all of which might give rise to CVD
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    Low Testosterone is a very significant problem in men with type II Diabetes.  Estimated to reach 40%, likely much higher.  They based these estimates only on T levels and sexual symptoms. Testosterone improves glycemic control primarily through Increased transcription and transloction of GLUT4 insulin receptors to the cell surface.  Inflammation reduction is also a mechanism.  Testosteorne lowers Triglycerides in the traditional lipid profile.  Studies are mixed on the other aspects of  lipids.  
Nathan Goodyear

Dietary composition in the treatment of polycystic ovary syndrome: a systematic review ... - 0 views

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    Weight loss is the best positive effect for women with PCOS.  Higher fat and protein, with a lower carb diet benefited women with PCOS.  A low Glycemic index plan benefited women with PCOS.  
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